Ambiguity, Familiarity and Learning Behavior in the Adoption of ICT for Irrigation Management

Subjective behavior of decision makers (DMs) is paramount when modeling information and communication technology (ICT) adoption choices in irrigated agriculture. Here, efficient ICT aided irrigation plans often involve a certain degree of uncertainty, and differential attitudes toward it can cause uncoordinated actions between actors. Some DMs will implement ICT information, while others will not because they do not trust ICT reliability. This risks undermining the achievement of ICT benefits in terms of water saving at the irrigation district level. By distinguishing between differ ent sources of uncertainty, taking the form of risk and ambiguity, in the present paper, we developed a new decision model to assess the impact that subjective behavior and learning processes have on the efficiency of ICT-aided irrigation plans. A case study was selected to implement the model in simplified settings. The results revealed the potential of ambiguity to limit ICT information implemen tation and to hinder water governance. Implications mainly concern the development of uncertainty management policies to favor DMs becoming familiar with the new ICT with lower ambiguit

Noninvasive ventilation for acute exacerbations of chronic obstructive pulmonary disease in the emergency department: early predictors of in-hospital outcome

The applications of early non-invasive ventilation (NIV) are nowadays expanding in the Emergency Department (ED) for the treatment of different types and etiologies of acute respiratory failure (ARF) Emergency physicians (EP) often face the challenge of predicting short-term outcomes for patients with ARF in the E

Design of mechanical properties of poly(butylene-adipate-terephthalate) reinforced with Zein-TiO2 complex

The aim of this work was to realize and mechanically characterize composites based on poly(butyleneadipate-terephthalate) (PBAT) filled with micrometric particles of zein-TiO2 complex (ZTC) at different concentrations. Specimens model 1BA were obtained by injection molding and subjected to a uniaxial tensile test (UTT). The addition of the ZTC proved to have a reinforcing effect on the matrix, an increase in both Young’s modulus (E) and yield stress (σy) being observed. The mechanical properties were modeled applying Kerner’s and Pukánszky’s models, obtaining a good correspondence between theoretical experimental values and good matrix-filler interfacial interaction, respectively. Microscopical analysis revealed a good dispersion of the filler within the matrix

Allosteric inhibition of Aurora-A kinase by a synthetic vNAR domain

The vast majority of clinically-approved protein kinase inhibitors target the ATP binding pocket directly. Consequently, many inhibitors have broad selectivity profiles and most have significant off-target effects. Allosteric inhibitors are generally more selective, but are difficult to identify because allosteric binding sites are often unknown or poorly characterized. Aurora-A is activated through binding of TPX2 to an allosteric site on the kinase catalytic domain, and this knowledge could be exploited to generate an inhibitor. Here, we generated an allosteric inhibitor of Aurora-A kinase based on a synthetic, vNAR single domain scaffold, vNAR-D01. Biochemical studies and a crystal structure of the Aurora-A/vNAR-D01 complex show that the vNAR domain stabilizes an inactive conformation, in which the αC-helix is distorted, the canonical Lys-Glu salt bridge is broken, and the regulatory (R-) spine is disrupted by an additional hydrophobic side chain from the activation loop. These studies illustrate how single domain antibodies can be used to characterize the regulatory mechanisms of kinases and provide a rational basis for structure-guided design of allosteric Aurora-A kinase inhibitors

Playing in or out of character: User role differences in the experience of Interactive Storytelling

Interactive storytelling (IS) is a promising new entertainment technology synthesizing preauthored narrative with dynamic user interaction. Existing IS prototypes employ different modes to involve users in a story, ranging from individual avatar control to comprehensive control over the virtual environment. The current experiment tested whether different player modes (exerting local vs. global influence) yield different user experiences (e.g., senses of immersion vs. control). A within-subject design involved 34 participants playing the cinematic IS drama "Emo Emma

Controlling Narrative Generation with Planning Trajectories: The Role of Constraints

Abstract. AI planning has featured in a number of Interactive Storytelling prototypes: since narratives can be naturally modelled as a sequence of actions it has been possible to exploit state of the art planners in the task of narrative generation. However the characteristics of a “good ” plan, such as optimality, aren’t necessarily the same as those of a “good ” narrative, where errors and convoluted sequences may offer more reader interest, so some narrative structuring is required. In our work we have looked at injecting narrative control into plan generation through the use of PDDL3.0 state trajectory constraints which enable us to express narrative control information within the planning representation. As part of this we have developed an approach to planning with such trajectory constraints. The approach decomposes the problem into a set of smaller subproblems using the temporal orderings described by the constraints and then solves these subproblems incrementally. In this paper we outline our method and present results that illustrate the potential of the approach.

Complexes With Biologically Active Ligands. Part 111. Synthesis and Carbonic Anhydrase Inhibitory Activity of Metal Complexes of 4,5-Disubstituted-3-Mercapto-1,2,4-Triazole Derivatives

Complexes containing five 4,5-disubstituted-3-mercapto-1,2,4-triazoles and Zn(II), Hg(II) and Cu(I) were synthesized and characterized by standard procedures (elemental analysis; IR, electronic and NMR spectroscopy, conductimetry and TG analysis). Both the thione as well as the thiolate forms of the ligands were evidenced to interact with the metal ions in the prepared complexes. The original mercaptans and their metal complexes behave as inhibitors of three carbonic anhydrase (CA) isozymes, CA I, II and IV, but did not lower intraocular pressure in rabbits in animal models of glaucoma